Not known Facts About phenobarbital sodium injection dailymed
Not known Facts About phenobarbital sodium injection dailymed
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pentobarbital will increase levels of vortioxetine by escalating metabolism. Modify Therapy/Watch Intently. Consider raising the vortioxetine dose when coadministered with robust CYP inducers for >14 days; never to exceed three occasions unique vortioxetine dose.
Contraindicated (1)pentobarbital will lessen the level or effect of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital raises toxicity of methoxyflurane by increasing metabolism. Contraindicated. Amplified metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will reduce the extent or effect of bazedoxifene/conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the extent or effect of atorvastatin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will decrease the level or effect of pantoprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Not known.
pentobarbital will decrease the extent or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. The efficacy of hormonal contraceptives may be decreased.
Keep track of Carefully (1)pentobarbital will decrease the extent or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some reduce in fentanyl plasma concentrations, lack of efficacy or, perhaps, progress of a withdrawal syndrome within a affected person who has formulated Bodily dependence to fentanyl. Right after stopping a CYP3A4 inducer, given that the effects in the inducer decline, the fentanyl plasma concentration will boost which could maximize or prolong equally the therapeutic and adverse effects.
pentobarbital will minimize the level or effect of diclofenac by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Unidentified.
fentanyl transmucosal and pentobarbital equally raise sedation. Stay clear of or Use Alternate Drug. Restrict use to clients for whom alternative treatment method solutions are insufficient
Contraindicated (one)pentobarbital will lower the level or effect of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. read more Sturdy or moderate CYP3A4 inducers may possibly enhance amount of diazepam elimination; hence, efficacy of diazepam might be reduced.
pentobarbital will lessen the level or effect of paclitaxel protein certain by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
pentobarbital will reduce the extent or effect of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Consider a rise in cannabidiol dosage (based on medical response and tolerability) when coadministered with a robust CYP3A4 inducer.